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Overall survival in myelodysplastic syndromes (MDS)

Overall survival in myelodysplastic syndromes (MDS)

In myelodysplastic syndromes (MDS), anemia and transfusion burden critically impact overall survival (OS)1-3

  • Patients with lower-risk MDS experience significant mortality4
  • Severe anemia in MDS shortens patients’ lives and is associated with a more rapid evolution to acute myeloid leukemia (AML)1
  • Transfusion dependence also contributes to poorer OS1-3

Lower-risk MDS can take years away from patients’ lives4*

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<5 years

Median OS

*Analysis of 2396 patients from a prospective, noninterventional, longitudinal registry from January 2008 to December 2018, followed up to December 2019.4

Anemia and transfusions may negatively impact patients' lives1-3

Blood drop icon with text saying "50% shorter median OS"

Hgb levels 8-<10 g/dL are associated with a ~50% shorter median OS than Hgb levels ≥10 g/dL1†

†Analysis based on combined international databases of 7012 patients with primary untreated MDS.1

Arrow icon pointing down with text saying "59% lower risk of death"

Transfusion independence is associated with a 59% decreased risk of death for patients2‡

[HR 0.41; 95% credible interval (CrI) 0.29-0.56]

‡According to a meta-analysis of 89 publications on the association between OS and transfusion independence in patients with MDS.2

Actively manage Hgb levels and transfusion burden to improve survival in MDS1-3

References:

1. Greenberg PL, Tuechler H, Schanz J, et al. Revised International Prognostic Scoring System for myelodysplastic syndromes. Blood. 2012;120(12):2454-2465. 2. Harnan S, Ren S, Gomersall T, et al. Association between transfusion status and overall survival in patients with myelodysplastic syndromes: a systemic literature review and meta-anlaysis. Acta Haematol. 2016;136(1):23-42. 3. Malcovati L, Della Porta MG, Cazzola M. Predicting survival and leukemic evolution in patients with myelodysplastic syndrome. Haematologica. 2006;91(12):1588-1590. 4. Madry K, Lis K, Fenaux P, et al. Cause of death and excess mortality in patients with lower-risk myelodysplastic syndromes (MDS): a report from the European MDS registry. Br J Haematol. 2023;200(4):451-461.